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Stem Cells Scientific References

Clinical Trials

  • Vangsness CT, A Randomized Clinical Trial Using Mesenchymal Stem Cells for Meniscus Regeneration and Osteoarthritis, double-blind human trial, 55 subjects, meniscus tears, statistically significant reduction in pain from Stem cells compared to placebo; degenerative bone changes 3.5 times more likely with placebo then stem cells; No serious adverse effects observed at 2 years post treatment.
  • A number of clinical trials are in progress, not many have been completed with definitive results yet.

Non-Clinical Studies

  • Pascual-Garrido C, et al., Treatment of chronic patellar tendinopathy with autologous bone marrow stem cells: a 5-year-followupStem Cells Int. 2012;2012:953510. doi: 10.1155/2012/953510. Epub 2011 Dec 18.  Only 8 patients; statistically significant improvements in clinical scores; 7 out of 8 patients thought procedure excellent and would do it on their other knee if needed
  • Gobbi A, One-Step Cartilage Repair with Bone Marrow Aspirate Concentrated Cells and Collagen Matrix in Full-Thickness Knee Cartilage Lesions. Results at 2-Year Follow-up.  Patients showed significant improvements.  MRI showed tissue regrowth in all patients.  No adverse reactions or post-operative complications noted.
  • Henrich C et al., Safety of autologous bone marrow aspiration concentrate transplantation: initial experiences in 101 patients, Orthop Rev (Pavia). 2009 Oct 10;1(2):e32. doi: 10.4081/or.2009.e32. 101 patients with bone healing disturbances; 2 needed further surgeries; all resolved with no complications.
  • Marcus Jager, Bone Marrow Concentrate: A Novel Strategy for Bone Defect Treatment, Current Stem Cell Research & Therapy, 2009, 4, 34-43. Transplantation of Bone Marrow Aspirate was able to facilitate healing of volumetric bone loss.  All patients showed bone healing and/or sufficient new bone formation.
  • Fortier L, Concentrated Bone Marrow Aspirate Improves Full-Thickness Cartilage Repair Compared with Microfracture in the Equine Model, 2010 Journal Of Bone and joint Surgery. Bone Marrow Concentrate can result in healing of acute full-thickness cartilage defects superior to microfracture alone in an equine model.  MRIs showed increased fill of defects and improved integration of repair tissue into surrounding normal cartilage.