Platelet Rich Plasma (PRP) Scientific References

Review of Existing Science

  • Christopher Allan Webb, PA-CPlatelet-Rich Plasma Update: Clinical Use in Musculoskeletal Care, Journal of Musculoskeletal Medicine, 2012; 29:96-101, mixed reviews, a number of positive studies but more are needed
  • Marx RE, Platelet-rich plasma: evidence to support its use, Journal of Oral and Maxillofacial Surgery 2004 62 (4): 489–96. doi:10.1016/j.joms.2003.12.003. PMID 15085519. Dentistry, 10x concentrate best, shows Harvest machine produces highest concentration

Randomized/Blind/Controlled Trials

  • Mishra AK, MD et al., Platelet Rich Plasma Significantly Improves Clinical Outcomes in Patients With Tennis Elbow, A Double-Blind, Prospective, Multicenter, Controlled Trial of 230 Patientspresented at the American Association of Orthopedic Surgeons (AAOS) in Chicago, Mar. 21, 2013, Tendon: Tennis Elbow; 71% improvement at 24 months
  • Peerbooms JC, Sluimer J, Bruijn DJ, Gosens TPositive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up, American Journal of Sports Medicine, 2010;38:255-262, Tendon: (Chronic Lateral) Epicondylitis; 73% lasting success with PRP
  • Vogrin M, Rupreht M, Crnjac A, et al.The effect of platelet-derived growth factors on knee stability after anterior cruciate ligament reconstruction: a prospective randomized clinical studyWien Klin Wochenschr. 2010;122(suppl 2):91-95, ACL; significantly better knee stability with PRP
  • Wassim Raffoul, PD, Effect of Platelet Rich Plasma and Keratinocyte Suspensions on Wound Healing, ClinicalTrials.gov Identifier: NCT00856934January/February 2009, Wound healing; PRP + keratinocytes dramatically reduces healing times (50%) and pain (80-95%) if sprayed on wound dressings
  • Clinicaltrials.gov: 109 PRP trials listed at time of search in 2013, only 36 completed, around 10 of them not PRP relevant, so really only 26 trials with results:
    • Most trials found that PRP reduces pain, at least in the short term.  Some found that it greatly diminishes the rate of re-tears and probably strengthens structural integrity. 
    • 2 trials found that PRP helps collagen generation in skin and also helps diminish nasolabial folds
    • 1 trial found significant pain reduction and cure in chronic (tennis) elbow tendinosis
    • 1 trial found faster return to activity after Achilles tendon tear repairs (part of surgery)